Isradipine

SKU: orb1224061

Description

Isradipine is a potent and selective L-type voltage-gated calcium channel blocker, used to treat high blood pressure.(In Vitro):Isradipine has much higher (＞40 fold) affinity for Cav1.3 channels as well as good brain bioavailability. Isradipine has nearly equal potency at Cav1.2 and Cav1.3 channels.(In Vivo):Isradipine (0.1~3 mg/kg; p.o.) makes sodium excretion increase in a dose-dependent manner.Isradipine pre-treatment reduces 6-hydroxydopamine induced neurotoxicity at the striatal level. Protective effect of isradipine at the striatal level is dose-dependent as shown from 6 mice. Isradipine pre-treatment increases the number of surviving SNc DA cells after 6-hydroxydopamine induced degeneration. Isradipine is capable of protecting striatal dopaminergic terminals and SNc dopaminergic cell bodies against a slow, progressive insult created by intrastriatal injection of 6-hydroxydopamine.

Key Properties

• CAS Number: 75695-93-1
• MW: 371.39
• Purity: >98% (HPLC)
• Formula: C₁₉H₂₁N₃O₅
• SMILES: CC1=C(C(OC)=O)C(C2=CC=CC3=NON=C32)C(C(OC(C)C)=O)=C(C)N1
• Target: Calcium Channel
• Solubility: Ethanol: 74 mg/mL warmed (199.25 mM); DMSO: 74 mg/mL (199.25 mM)

Bioactivity

• In Vivo:
  Isradipine (0.1~3 mg/kg; p.o.) makes sodium excretion increase in a dose-dependent manner. Isradipine pre-treatment reduces 6-hydroxydopamine induced neurotoxicity at the striatal level. Protective effect of isradipine at the striatal level is dose-dependent as shown from 6 mice. Isradipine pre-treatment increases the number of surviving SNc DA cells after 6-hydroxydopamine induced degeneration. Isradipine is capable of protecting striatal dopaminergic terminals and SNc dopaminergic cell bodies against a slow, progressive insult created by intrastriatal injection of 6-hydroxydopamine. Animal model: Rats. Dosage: 0.1~3 mg/kg. Administration: p.o. Result: Sodium excretion increased in a dose-dependent manner. .
• In Vitro:
  Isradipine has much higher (>40 fold) affinity for Cav1.3 channels as well as good brain bioavailability. Isradipine has nearly equal potency at Cav1.2 and Cav1.3 channels.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PN 200-110

Quick Database Links

Gene Symbol

Calcium Channel