Isolongifolene

SKU: orb1219087

Description

Isolongifolene has antioxidant, anti-inflammatory, anticancer and neuroprotective properties. Isolongifolene is a tricyclic sesquiterpene isolated from Murraya koenigii. Isolongifolene attenuates Rotenone-induced oxidative stress, mitochondrial dysfunction and apoptosis through the regulation of P13K/AKT/GSK-3β signaling pathways.

Key Properties

• CAS Number: 1135-66-6
• MW: 204.35
• Purity: >98% (HPLC)
• Formula: C₁₅H₂₄
• SMILES: CC1(C)[C@]23CC[C@](C3)([H])C(C)(C)C2=CCC1
• Target: Others
• Solubility: DMSO:10 mM

Bioactivity

• In Vitro:
  Isolongifolene (0-50 μM; 26 hours; SH-SY5Y neuroblastoma cells) treatment significantly alleviates Rotenone-induced cytotoxicity in SH-SY5Y cells in a dose-dependent manner. Isolongifolene (10 μM; 26 hours; SH-SY5Y neuroblastoma cells) treatment attenuates Rotenone-induced apoptosis in SH-SY5Y cells. Isolongifolene (10 μM; 26 hours; SH-SY5Y neuroblastoma cells) treatment attenuates Rotenone induced toxicity by down-regulating Bax, caspases-3, 6, 8 and 9 expression and up-regulating of Bcl-2 expression. Furthermore regulation of p-P13K, p-AKT and p-GSK-3β expression by Isolongifolene. Cell Viability Assay Cell line: SH-SY5Y neuroblastoma cells. Concentration: 0 μM, 1 μM, 2.5 μM, 5 μM, 10 μM, 20 μM and 50 μM Incubation time: 26 hours. Result: Significantly alleviated Rotenone-induced cytotoxicity in SH-SY5Y cells. Apoptosis Analysis Cell line: SH-SY5Y neuroblastoma cells. Concentration: 10 μM. Incubation time: 26 hours. Result: Attenuated Rotenone-induced apoptosis in SH-SY5Y cells. Western blot analysis. Cell line: SH-SY5Y neuroblastoma cells. Concentration: 10 μM. Incubation time: 26 hours. Result: Attenuated rotenone induced toxicity by down-regulatingBax, caspases-3, 6, 8 and 9 expression and up-regulating of Bcl-2 expression. Prevented the rotenone-induced decreased phosphorylation of GSK-3β.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

(-)-Isolongifolene

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Gene Symbol

Others