Irigenin

SKU: orb1303647

Description

Irigenin is a small molecule that exerts antimetastatic effects by selectively inhibiting α9β1 and α4β1 integrin binding to the Extra Domain A C-C loop. It also sensitizes gastric cancer cells to TRAIL-induced apoptosis in vitro by upregulating pro-apoptotic proteins, highlighting its utility in cancer mechanism and therapy research.

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 548-76-5
• MW: 360.31
• Purity: 99.85% (May vary between batches)
• Formula: C₁₈H₁₆O₈
• SMILES: COc1cc(cc(O)c1OC)-c1coc2cc(O)c(OC)c(O)c2c1=O
• Target: Apoptosis,Integrin,NF-κB
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.55 mM);DMSO:65 mg/mL (180.4 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

TRAIL, transition, NF-kB, NFkB, NFκB, NF-κB, metastasis, lung, loop, inhibit, Irigenin, Inhibitor, Integrin, gastric, Epithelial-Mesenchymal, EDA, carcinoma, cancer, apoptosis, C-C

Compound Identifiers

PubChem CID

5464170