Irigenin

SKU: orb1222063

Description

Irigenin has antifungal activity.

Key Properties

• CAS Number: 548-76-5
• MW: 360.32
• Purity: >98% (HPLC)
• Formula: C₁₈H₁₆O₈
• SMILES: COc1cc(cc(c1OC)O)c1coc2cc(c(c(c2c1=O)O)OC)O
• Target: NF-κB
• Solubility: In Vitro: DMSO : 100 mg/mL (277.54 mM)

Bioactivity

• In Vitro:
  Irigenin specifically targets α9β1 and α4β1 integrin binding sites on Extra Domain A (EDA) comprising LEU46, PHE47, PRO48, GLU58, LEU59 and GLN60 in its C-C loop. Irigenin binds to the C-C loop of EDA, thereby blocking its interaction with integrins on the cell surface and thus abrogating subsequent Epithelial-Mesenchymal transition.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

NF-κB