IRES-C11

SKU: orb2813909

Description

IRES-C11 is a selective small molecule inhibitor that disrupts c-MYC translation by blocking the hnRNP A1 interaction with its IRES, without affecting IRES activity of BAG-1, XIAP, or p53. It is a valuable research tool for studying oncogene expression and has been utilized in both in vitro and in vivo models to investigate c-MYC-driven cancers.

Research Area

Cell Biology

Key Properties

• CAS Number: 342416-30-2
• MW: 316.14
• Purity: 99.89% (May vary between batches)
• Formula: C₁₃H₁₁Cl₂NO₄
• SMILES: COc1ccc(CN2C(=O)C(Cl)=C(Cl)C2=O)c(OC)c1
• Target: c-Myc
• Solubility: DMSO:225 mg/mL (711.71 mM)

Bioactivity

• In Vitro:
  IRES-C11 (50 nM) significantly inhibits both cyclin D1 and c-MYC IRES activity. IRES-C11 treatment induces a significant shift in both cyclin D1 and c-MYC mRNA to monosomal/nonribosomal fractions, whereas actin mRNA distribution is unaffected. IRES-C11 inhibits both cyclin D1 and c-MYC IRES-mediated mRNA translation, leading to reductions in protein levels. Mechanistic studies with IRES-C11 reveal the binding of the inhibitors within the UP1 fragment of heterogeneous nuclear ribonucleoprotein A1.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

IRES C11, IRESC11, IRES-C11, IRES-C-11, c-Myc, cMyc

Compound Identifiers

PubChem CID

353999