IRES-J007

SKU: orb1473143

Description

IRES-J007 ia an improved IRES inhibitor that blocks IRES-hnRNP A1 binding; binds to a small pocket structure within the RRM-containing fragment of hnRNP A1 (UP1 fragment), inhibits cyclin D1 and c-MYC IRES activity to a greater extent compared with C11 (IRES-C11); significantly reduces tumor growth of GBM xenografts in mice, and markedly reduces the mRNA translational state of cyclin D1 and c-MYC transcripts combined with PP242.

Key Properties

• CAS Number: 155514-72-0
• MW: 297.3053
• Purity: >98%
• Formula: C₁₇H₁₅NO₄
• SMILES: O(C([H])([H])[H])C1C([H])=C(C([H])=C([H])C=1C([H])([H])N1C(C2=C([H])C([H])=C([H])C([H])=C2C1=O)=O)OC([H])([H])[H]

Storage & Handling

• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

12013928