Intetumumab Antibody

SKU: orb1980631

Description

Intetumumab (CNTO 95) is a fully human monoclonal antibody targeting α(v)-integrins. It acts as a radiosensitizer and demonstrates anti-tumor and anti-metastatic activity, as shown in A549 non-small cell lung cancer xenograft models. This makes it a valuable research tool for studying angiogenesis, metastasis, and combination therapies in oncology.

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• CAS Number: 725735-28-4
• MW: 145.6 (kDa)
• Purity: 97.6% (SDS-PAGE); 97.1% (SEC-HPLC)
• Target: EGFR,Integrin

Bioactivity

• In Vivo:
  Intetumumab administered intraperitoneally at a dose of 10 mg/kg to male nude mice was able to reduce the growth of A549 tumors and inhibit their spontaneous lung metastasis, as well as to reduce the number of mice presenting with lung metastases and the number of metastatic lesions per lung.
• In Vitro:
  Intetumumab was able to inhibit integrin-mediated attachment of USPC-ARK-3 cells to the hyaluronan matrix and inhibit serum-induced migration of USPC cells at concentrations ranging from 0 to 5 μg/mL and treatment for 20 minutes.

Storage & Handling

• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

EGFR, Anti-Human CD51 Recombinant Antibody, CNTO 095, CNTO 95, CNTO095, CNTO95

Quick Database Links

Gene Symbol

EGFR,Integrin