Inosine

SKU: orb1310617

Description

Inosine, an endogenous purine nucleoside metabolite of adenosine, acts as an agonist at adenosine A1 and A2A receptors. It is widely used in research for its neuroprotective, anti-inflammatory, and immunomodulatory properties, with applications in both in vitro and in vivo models of ischemia, inflammation, and pain.

Research Area

Immunology & Inflammation, Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 58-63-9
• MW: 268.23
• Purity: 99.51% (May vary between batches)
• Formula: C₁₀H₁₂N₄O₅
• SMILES: O[C@H]1[C@H](N2C3=C(N=C2)C(=O)N=CN3)O[C@H](CO)[C@H]1O
• Target: Endogenous Metabolite,Adenosine Receptor,ROS
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (18.64 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble);DMSO:245 mg/mL (913.4 mM);H2O:43 mg/mL (160.31 mM)

Bioactivity

• Target IC50:
  PvENT1:3.8 μM
• In Vivo:
  METHODS: To study the analgesic effect of Inosine, Inosine (1 mg/kg, 10 mg/kg, and 100 mg/kg) was injected intraperitoneally to mice 20 min before formalin treatment. RESULTS: Inosine reduced formalin-induced leg withdrawal.
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• In Vitro:
  METHODS: Rat C6, DU-145, HaCaT, L6, and MCF7 cells were treated with Inosine (0-250 μM) for 48 hours, and MTT assay was used to detect the inhibition of cell growth. RESULTS: Inosine did not inhibit the growth of C6, DU-145, HaCaT, L6 and MCF7 cells at 250 μM.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

XO, P1 receptor, disease, Adenosine Receptor, adenosine, AdenosineReceptor, antinociceptive, antihyperalgesic, antiallodynic, EndogenousMetabolite, Endogenous Metabolite, human, INO 495, INO495, INO-495, Inosine, Inhibitor, NSC 20262, inhibit, immunomodulatory, metabolite, metabolism, Parkinson's, NSC20262, NSC-20262, neuroprotective, nucleoside

Compound Identifiers

PubChem CID

136265389