Inosine

SKU: orb1224575

Description

A purine nucleoside that has hypoxanthine linked by the N9 nitrogen to the C1 carbon of ribose. It is an intermediate in the degradation of purines and purine nucleosides to uric acid and in pathways of purine salvage. It also occurs in the anticodon of certain transfer RNA molecules.(In Vitro):Inosine dose-dependently stimulates cAMP production mediated through the A2AR.Inosine dose-dependently induces hA2AR-mediated ERK1/2 phosphorylation.Inosine (100 μM; 24 hours) reduces oxidative stress in MES 23.5 cells cultured with astrocytes.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 58-63-9
• MW: 268.23
• Purity: >98% (HPLC)
• Formula: C₁₀H₁₂N₄O₅
• SMILES: OC[C@@H]1[C@H]([C@H]([C@H](N2C=NC3=C(N=CN=C32)O)O1)O)O
• Target: ROS
• Solubility: Water: 47 mg/mL warmed (175.22 mM); DMSO: 53 mg/mL warmed (197.59 mM)

Bioactivity

• In Vivo:
  Animal model: Male/female C57BL/6 mice. Dosage: 1 mg/kg, 10 mg/kg, 100 mg/kg. Administration: Intraperitoneal injection, 20 min before formalin treatment. Result: Reduced flinching behaviour induced by formalin (2 %; 20 μL; intraplantar injection).
• In Vitro:
  Inosine dose-dependently stimulates cAMP production mediated through the A2AR. Inosine dose-dependently induces hA2AR-mediated ERK1/2 phosphorylation. Inosine (100 μM; 24 hours) reduces oxidative stress in MES 23.5 cells cultured with astrocytes.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inosine | NSC 20262 | NSC-20262 | NSC20262

Quick Database Links

Gene Symbol

ROS