INH1

SKU: orb1305386

Description

INH1 (IBT13131) is a cell-permeable small molecule that inhibits Hec1 by disrupting its interaction with Nek2. This compound is used in vitro to study mitotic progression and has been applied in vivo to investigate its effects on tumor growth in cancer research models.

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 313553-47-8
• MW: 308.4
• Purity: >99.99% (May vary between batches)
• Formula: C₁₈H₁₆N₂OS
• SMILES: Cc1ccc(-c2csc(NC(=O)c3ccccc3)n2)c(C)c1
• Target: Microtubule Associated,Apoptosis,MAPK
• Solubility: DMSO:30.8 mg/mL (99.87 mM);Ethanol:3.1 mg/mL (10.05 mM)

Bioactivity

• Target IC50:
  Hec1:10-21 μM
• In Vivo:
  INH1 effectively inhibits the proliferation of human breast cancer cells with a GI50 of 10-21 μM. Additionally, INH1 induces cell-killing activity by disrupting the spindle checkpoint-regulated Hec1/Nek2 pathway.
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• In Vitro:
  Intraperitoneal injection of 100 mg/kg INH1 inhibits the growth of mammary tumors in mice with MDA-MB-468 human breast cancer xenografts.
• Cell Research:
  Standard 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assays with a 3-d drug treatment procedure are performed to measure the dose-dependent cytotoxicity of INH1 in cultured cells. Triplicate sets are measured and compiled for final data presentation.(Only for Reference)
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Apoptosis, inhibit, INH 1, INH1, INH-1, MicrotubuleAssociated, Microtubule Associated, Hec1, Inhibitor, IBT 13131, IBT13131, IBT-13131

Compound Identifiers

PubChem CID

959043