Indomethacin sodium hydrate

SKU: orb1704821

Description

Indomethacin sodium hydrate is a potent, orally bioavailable dual COX-1/COX-2 inhibitor used in research on inflammation, cancer, and infection. It is applied in vitro and in vivo to model conditions such as rheumatoid arthritis, gastric ulcers, and traumatic brain injury-related intracranial pressure.

Research Area

Immunology & Inflammation, Neuroscience

Key Properties

• CAS Number: 74252-25-8
• MW: 433.82
• Purity: 99.45% (May vary between batches)
• Formula: C₁₉H₂₁ClNNaO₇
• SMILES: O=C([O-])CC1=C(N(C2=C1C=C(OC)C=C2)C(C3=CC=C(Cl)C=C3)=O)C.[Na+].O.O.O
• Target: COX
• Solubility: DMSO:5 mg/mL (11.53 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.31 mM);H2O:20 mg/mL (46.1 mM)

Bioactivity

• In Vivo:
  In male Sprague-Dawley rats, Indomethacin sodium hydrate (0.01-10 mg/kg; oral administration; for 3 hours) inhibited carrageenan-induced paw edema and hyperalgesia in a dose-dependent manner, with an ED50 of 2.0 mg/kg for paw edema and 1.5 mg/kg for hyperalgesia.
• In Vitro:
  In 3LL-D122 cells, Indomethacin sodium hydrate (0, 20, 50, 100, and 150 μM; 24 hours) inhibited cell viability, with inhibition observed at 20 mM and 50% inhibition at 60 mM.

Storage & Handling

• Storage: store under nitrogen,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

COX-1, COX-2, 18828-58-5, Indometacin Sodium, Indometacin sodium hydrate

Compound Identifiers

PubChem CID

23674731