Indomethacin sodium hydrate

SKU: orb2901488

Description

Indomethacin (Indometacin) sodium hydrateis a potent, orally active COX1/2inhibitor with IC50 values of 18 nM and 26 nM for COX-1 and COX-2, respectively. Indomethacin sodium hydrateis has anticancer activity and anti-infective activity. Indomethacin sodium hydrateis can be used for cancer, inflammation and viral infection research.

Key Properties

• CAS Number: 74252-25-8
• MW: 433.82
• Purity: >98% (HPLC)
• Formula: C₁₉H₂₁ClNNaO₇
• SMILES: O=C([O-])CC1=C(N(C2=C1C=C(OC)C=C2)C(C3=CC=C(Cl)C=C3)=O)C.[Na+].O.O.O
• Target: COX
• Solubility: In Vitro: H2O : 25 mg/mL (57.63 mM; Ultrasonic)DMSO : 12.5 mg/mL (28.81 mM; Ultrasonic (<60°C)

Bioactivity

• In Vivo:
  Animal model: Male Sprague-Dawley rats. Dosage: 0.01-10 mg/kg. Administration: Oral administration; for 3 hours. Result: Inhibited the carrageenan-induced rat paw oedema (ED50 = 2.0 mg/kg) and hyperalgesia (ED50 = 1.5 mg/kg) in a dose-dependent manner. Animal model: Male C57BL/6J mice. Dosage: 10 mg/mL. Administration: Oral administration; daily, for 29 days. Result: Delayed the onset of tumor growth and the initial growth rate of the footpad tumors.
• In Vitro:
  Cell Viability Assay Cell line: 3LL-D122 cells (highly metastatic variant of mouse LLcarcinoma cells). Concentration: 0, 20, 50, 100 and 150 μM. Incubation time: 24 hours. Result: Inhibited cell viability at 20 mM, with 50% inhibition at 60 mM. Cell Cycle Analysis Cell line: 3LL-D122 cells (highly metastatic variant of mouse LLcarcinoma cells). Concentration: 0, 30 and 80 μM. Incubation time: 24 hours. Result: Decreased in the percentage of cells at the G2/M phase and increased in the percentage of cells at G1 phase.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

COX