Indobufen

SKU: orb1940718

Description

Indobufen is an inhibitor of platelet aggregation and is a reversible platelet cyclooxygenase (Cox) activity inhibitor. Indobufen suppresses thromboxane A2 (TxA2) synthesis. Indobufen down-regulates tissue factor (TF) in monocytes.(In Vitro):Indobufen suppresses TxA2 but not PGE2 synthesis in LPS-stimulated monocytes. Indobufen causes the extent of ERK1/2 phosphorylation, whereas the levels of phosphorylated p38 are unaltered. Indobufen does not affect both Cox-1 and Cox-2 protein, whereas Indobufen reduces TxB2 levels.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 63610-08-2
• MW: 295.338
• Purity: >98% (HPLC)
• Formula: C₁₈H₁₇NO₃
• SMILES: CCC(C(O)=O)c1ccc(cc1)N1Cc2ccccc2C1=O
• Target: COX
• Solubility: In Vitro: DMSO : 250 mg/mL (846.51 mM)

Bioactivity

• In Vitro:
  Indobufen does not affect both Cox-1 and Cox-2 protein, whereas Indobufen reduces TxB2 levels. Indobufen inhibits TxA2 but not PGE2 synthesis in LPS-stimulated monocytes. Indobufen reduces the extent of ERK1/2 phosphorylation, whereas the levels of phosphorylated p38 are unaltered.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Ibustrin

Quick Database Links

Gene Symbol

COX