Indobufen

SKU: orb1308195

Description

Indobufen (Ibustrin) is a reversible, small-molecule inhibitor of platelet cyclooxygenase (COX) that suppresses thromboxane A2 synthesis and platelet aggregation. It also downregulates monocyte tissue factor expression, making it a useful research tool for studying thrombosis and inflammation in both in vitro and in vivo models.

Research Area

Immunology & Inflammation, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 63610-08-2
• MW: 295.33
• Purity: 99.73% (May vary between batches)
• Formula: C₁₈H₁₇NO₃
• SMILES: O=C1N(CC=2C1=CC=CC2)C3=CC=C(C(C(O)=O)CC)C=C3
• Target: COX
• Solubility: DMSO:55 mg/mL (186.23 mM)

Bioactivity

• In Vitro:
  Indobufen suppresses TxA2 but not PGE2 synthesis in LPS-stimulated monocytes. Indobufen causes the extent of ERK1/2 phosphorylation, whereas the levels of phosphorylated p38 are unaltered. Indobufen does not affect both Cox-1 and Cox-2 protein, whereas Indobufen reduces TxB2 levels.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Indobufen, inhibit, Inhibitor, Ibustrin, COX, Cyclooxygenase

Compound Identifiers

PubChem CID

107641