Indirubin

SKU: orb1301015

Description

Indirubin

Research Area

Cell Biology, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 479-41-4
• MW: 262.26
• Purity: 99.74%
• Formula: C₁₆H₁₀N₂O₂
• SMILES: O=C1Nc2ccccc2C1=C1Nc2ccccc2C1=O
• Target: CDK,GSK-3,Raf,Apoptosis
• Solubility: DMSO:5 mg/mL (19.07 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble);H2O:< 1 mg/mL (insoluble or slightly soluble);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (3.81 mM)

Bioactivity

• Target IC50:
  Cyclin-dependent kinase:5 μM|GSK-3β:0.6 μM
• In Vitro:
  Indirubin is the active ingredient of Danggui Longhui Wan, a mixture of plants that is used in traditional Chinese medicine to treat chronic diseases. Indirubin inhibits CDKs activity with IC50 of 2.2 - 10 μM resulting in cell cycle arrest in the G2/M phase. Indirubin also inhibits GSK-3β with an IC50 of 0.6 μM, attenuating CDK5- and GSK-3β-mediated tau phosphorylation, a process over-active in Alzheimer disease states. It also suppresses tumor necrosis factor (TNF)-induced NF-κB activation in a dose- and time-dependent manner. Indirubin also suppresses the NF-κB activation induced by various inflammatory agents and carcinogens. Indirubin blocks the phosphorylation and degradation of IκBα through the inhibition of activation of IκBα kinase and phosphorylation and nuclear translocation of p65.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

p35-CDK5, GSK3, GSK-3β, Inhibitor, Indirubin, Indigo red, Indigopurpurin, NSC 105327, inhibit, NSC105327, NSC-105327, Couroupitine B, C-Raf, CDK1/CyclinB, CDK2/CyclinA, Apoptosis, anticancer

Compound Identifiers

PubChem CID

10177