Indirubin-3′-oxime

SKU: orb1298338

Description

Indirubin-3′-oxime is a potent cyclin-dependent kinase (CDK) inhibitor. Research indicates it is implicated in neuronal apoptosis pathways relevant to Alzheimer's disease, making it a valuable tool for in vitro and in vivo studies of neurodegeneration and cell cycle dysregulation.

Research Area

Cell Biology, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 667463-82-3
• MW: 277.28
• Purity: 98.34%
• Formula: C₁₆H₁₁N₃O₂
• SMILES: O\N=C1\C(\Nc2ccccc\12)=C1\C(=O)Nc2ccccc12
• Target: CDK,GSK-3,JNK
• Solubility: DMSO:55 mg/mL (198.36 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (7.21 mM)

Bioactivity

• Target IC50:
  JNK1:0.8 μM (IC50)|JNK2:1.4 μM (IC50)|JNK3:1 μM (IC50)
• In Vivo:
  indirubin-3'-monoxime improved the morphology and increased the survival rate of SH-SY5Y cells exposed to amyloid-beta 25-35 (Aβ25-35), and also suppressed apoptosis by reducing tau phosphorylation at Ser199 and Thr205. Furthermore, indirubin-3'-monoxime inhibited phosphorylation of glycogen synthase kinase-3β (GSK-3β). indirubin-3'-monoxime reduced Aβ25-35-induced apoptosis by suppressing tau hyperphosphorylation via a GSK-3β-mediated mechanism. Indirubin-3'-monoxime is a promising drug candidate for Alzheimer's disease.
• In Vitro:
  clear efficacy of I3M + Tq combinations in LC models mediated by suppressing Akt/mTOR/NFκB signalling.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

antiplatelet, chondrocytes, CDK, cdk, collagen, Cyclin dependent kinase, GSK3, GSK-3, Glycogen synthase kinase-3, Glycogen synthase kinase 3, IDR3O, I3O, Inhibitor, MEF2D, inhibit, Indirubin-3'-monoxime, indirubin, Indirubin 3′ oxime, Indirubin3′oxime, Indirubin-3′-oxime, induced, JNK, phosphorylation

Compound Identifiers

PubChem CID

3707