Indirubin-3-monoxime

SKU: orb1217749

Description

Indirubin-3-monoxime is an effective inhibitor of cyclin-dependent protein kinases, and may play an obligate role in neuronal apoptosis in Alzheimer's disease.

Key Properties

• CAS Number: 667463-82-3
• MW: 277.28
• Purity: >98% (HPLC)
• Formula: C₁₆H₁₁N₃O₂
• SMILES: Oc([nH]c1c2cccc1)c2-c([nH]c1c2cccc1)c2N=O
• Target: CDK
• Solubility: In Vitro: DMSO : 100 mg/mL (360.65 mM)

Bioactivity

• In Vivo:
  Indirubin-3′-oxime (0.05 or 0.5 mg/kg; i.p.; daily for 2 or 10 weeks) enhances tibial longitudinal growth in mice without adverse changes in bone thickness parameters. Animal model: Three-week-old C57BL/6 mice. Dosage: 0.05 or 0.5 mg/kg. Administration: i.p.; daily for 2 or 10 weeks. Result: The tibial length of mice increased in a dose-dependent manner.
• In Vitro:
  In cerebellar granule neurons (CGNs), Indirubin-3′-oxime blocks c-Jun phosphorylation induced by potassium withdrawal and prevented CGNs from apoptosis in a dose dependent manner. Indirubin-3′-oxime (IDR3O) (PC12 cells; 10 μM) significantly prevent 6OHDA-induced decrease of nuclear localized MEF2D expression.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

CDK