IMR-1A

SKU: orb1304088

Description

IMR-1A is the active metabolite of the Notch inhibitor IMR-1, functioning by blocking transcriptional activation with an IC50 of 6 µM. This small molecule is a valuable research tool for investigating the Notch signaling pathway in both cellular and animal models of cancer and other diseases.

Research Area

Metabolism Research, Neuroscience, Protein Biochemistry, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 331862-41-0
• MW: 325.36
• Purity: 99.86% (May vary between batches)
• Formula: C₁₃H₁₁NO₅S₂
• SMILES: COc1cc(\C=C2\SC(=S)NC2=O)ccc1OCC(O)=O
• Target: Gamma-secretase,Drug Metabolite
• Solubility: DMSO:4.23 mg/mL (13 mM)

Bioactivity

• Target IC50:
  IMR-1:6 μMol/L.
• In Vivo:
  The reference for intraperitoneal injection is 15 mg/kg. IMR-1 inhibits Notch-dependent somite development in zebrafish.
• In Vitro:
  IMR-1 prevents the recruitment of Maml1 to the NTC on chromatin, inhibits Notch target gene transcription, and dramatically inhibits tumor growth. A decrease in colony formation of Notch-dependent cell lines is observed upon treatment with IMR-1 when compared with the control (DMSO).
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DrugMetabolite, Drug Metabolite, Inhibitor, Notch, IMR 1A, IMR1A, IMR-1A, inhibit, Gammasecretase

Compound Identifiers

PubChem CID

1354721