IMR-1A

SKU: orb1223148

Description

IMR-1A is a metabolite of IMR-1. IMR-1A acts as Notch inhibitor and targeting gene transcription by disrupting Mam1 recruitment to chromatin.

Key Properties

• CAS Number: 331862-41-0
• MW: 325.36
• Purity: >98% (HPLC)
• Formula: C₁₃H₁₁NO₅S₂
• SMILES: O=C(O)COc1ccc(/C=C/2\SC(=S)NC2=O)cc1OC
• Target: Notch
• Solubility: DMSO : ≥ 31 mg/mL; 95.28 mM

Bioactivity

• In Vivo:
  IMR-1A (2 mg/kg (i. v.) and 100 mg/kg (i. p)) exhibits low systematic plasma clearance (CL = 7 mL/min/kg) with terminal elimination half-life (T1/2) of 2.22 h following a single i. v. administration. The normal liver blood flow in mice is 90 mL/min/kg and the Vss (volume of distribution) is ~4-fold. Plasma concentrations is quantifiable up to 24 h with Tmax of 0.50 h after i.p. administration. Animal model: Male C57 BL/6 mice. Dosage: 2 mg/kg (i. v.) and 100 mg/kg (i. p). Administration: I. v. and i.p. Result: Exhibited low systematic plasma clearance (CL = 7 mL/min/kg) with terminal elimination half-life (T1/2) of 2.22 h following a single i. v. administration and plasma concentrations isquantifiable up to 24 h with Tmax of 0.50 h after i.p. administration.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

IMR-1A | IMR 1A | Inhibitor of Mastermind Recruitment-1 Acid

Quick Database Links

Gene Symbol

Notch