IMM-H007

SKU: orb1298450

Description

IMM-H007 is a novel small molecule lipid-lowering agent that functions by upregulating ABCA1 protein expression. This mechanism supports its research applications in studying cholesterol efflux, atherosclerosis, and cardiovascular disease models in both cellular and animal studies.

Research Area

Cell Biology, Epigenetics & Chromatin, Metabolism Research, Molecular Biology, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 1221412-23-2
• MW: 485.45
• Purity: 97.73%
• Formula: C₂₂H₂₃N₅O₈
• SMILES: O(C(C)=O)[C@H]1[C@@H](O[C@H](COC(C)=O)[C@H]1OC(C)=O)N2C=3C(N=C2)=C(NC4=CC(O)=CC=C4)N=CN3
• Target: TGF-beta/Smad,JNK,AMPK,DNA/RNA Synthesis,HIF/HIF Prolyl-Hydroxylase,NF-κB
• Solubility: DMSO:22.5 mg/mL (46.35 mM)

Bioactivity

• In Vitro:
  IMM-H007 (H007) significantly inhibits monocyte adhesion to endothelial cells and its transendothelial migration. Mechanistically, H007 markedly represses TNFα-induced IκBα degradation and NF-κB nuclear translocation, therefore leading to NF-κB-mediated inflammatory suppression. Moreover, another inflammatory signaling JNK/c-Jun, which is always co-activated with NF-κB in response to pro-inflammatory stimuli, is also found to be restrained by H007 through reducing its phosphorylation status. H007 negatively regulates endothelium inflammation through inactivating NF-κB and JNK/AP1 signaling.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AMPK, AP-1, atherosclerosis, cardiac fibrosis, AMP-activated protein kinase, Activator Protein 1, IMM-H 007, IMMH007, IMM-H007, IMM-H-007, inflammatory, inhibit, JNK, JNK/c-Jun, Nonalcoholic fatty liver disease, Nuclear factor-kappaB, Nuclear factor-κB, NF-κB, NAFLD, IMM H007, Inhibitor, HIF ProlylHydroxylase, HIF Prolyl-Hydroxylase, HIF/HIF ProlylHydroxylase, HIF, HIFProlylHydroxylase, HIF/HIFProlylHydroxylase, WS070117, WS 070117, WS-070117, TGF-β Receptor, Transforming growth factor beta receptors

Compound Identifiers

PubChem CID

45377904