IMM-H007

SKU: orb1219022

Description

IMM-H007 is a novel lipid-lowering agent, increasing abca1 protein expression.

Key Properties

• CAS Number: 1221412-23-2
• MW: 369.4
• Purity: >98% (HPLC)
• Formula: C₁₈H₁₉N₅O₄
• SMILES: CC(=O)OC[C@H]1CC[C@@H](O1)N2C=NC3=C(N=CN=C32)NC4=CC(=CC=C4)O
• Target: Others
• Solubility: DMSO:10 mM

Bioactivity

• In Vivo:
  IMM-H007 inhibits fatty acid import into hepatocytes and liver lipogenesis, and concomitantly stimulates fatty acid oxidation, autophagy, and export of hepatic lipids. IMM-H007 (200 mg/kg, Orally, once per day for 10 days) inhibits ISO-induced cardiac fibrosis and diastolic dysfunction independently of AMPKα2 expression, reduces ISO-induced Smad2/3 phosphorylation downstream of TGFβ1 and cardiac fibrosis via an AMPKα2-independent pathway, but the inhibition of TGFβ1 expression is AMPKα2-dependent.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Others