Imiquimod

SKU: orb1310904

Description

Imiquimod (R 837) is a synthetic TLR7 agonist that functions as an immune response modifier with demonstrated antiviral and antitumor properties. It is widely used in research models of psoriasis and in studies investigating conditions such as viral warts, certain cancers, and COVID-19, utilizing both in vitro and in vivo experimental systems.

Research Area

Immunology & Inflammation, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 99011-02-6
• MW: 240.30
• Purity: >98%
• Formula: C₁₄H₁₄N₄
• SMILES: C(C(C)C)N1C=2C=3C(N=C(N)C2N=C1)=CC=CC3
• Target: TLR (Toll-like receptor)
• Solubility: Soluble in DMSO (up to 2 mg/ml with warming)

Bioactivity

• In Vivo:
  In animal models, imiquimod stimulates the innate immune response by increasing NK cell activity, activating macrophages to secrete cytokines and nitric oxide, and inducing proliferation and differentiation of B lymphocytes. Imiquimod stimulates the innate immune response through induction, synthesis, and release of cytokines, including interferon-a (IFN-α), interleukin (IL)-6, and tumour necrosis factor (TNF)-α.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

R837

Compound Identifiers

PubChem CID

57469