NBC 6

SKU: orb1685255

Description

NLRP3-IN-NBC6 is a selective small molecule inhibitor of the NLRP3 inflammasome with an IC50 of 574 nM. It functions independently of calcium signaling and effectively blocks nigericin-induced activation in THP-1 cells and imiquimod-induced IL-1β release in primed BMDMs. This compound is a valuable research tool for investigating NLRP3-driven pathologies in both cellular and animal models.

Research Area

Immunology & Inflammation

Key Properties

• CAS Number: 2068818-02-8
• MW: 409.5
• Formula: C₁₈H₁₆BCl₃N₂O₂
• SMILES: C(Cl)(Cl)(Cl)C1=[NH][B+3](O=C(N)[C-]1C(C)=O)([C-]=2C=CC=CC2)[C-]=3C=CC=CC3
• Target: NOD-like Receptor (NLR),Others

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

NOD-like Receptor (NLR),Others