IMD-0560

SKU: orb1308203

Description

IMD-0560 is a selective small molecule inhibitor targeting IKKβ, a key kinase in the NF-κB signaling pathway. It is utilized in research to investigate inflammatory diseases, cancer, and immune responses, with applications in both cellular (in vitro) and animal (in vivo) experimental models.

Research Area

Signal Transduction

Key Properties

• CAS Number: 439144-66-8
• MW: 428.12
• Purity: 99.78% (May vary between batches)
• Formula: C₁₅H₈BrF₆NO₂
• SMILES: Oc1ccc(Br)cc1C(=O)Nc1cc(ccc1C(F)(F)F)C(F)(F)F
• Target: IκB/IKK
• Solubility: Ethanol:50 mg/mL (116.79 mM)

Bioactivity

• In Vivo:
  Compare to the control groups, zygoma destruction is obviously suppressed in the IMD-0560-treated groups. In the IMD-0560-treated groups, the tumor size is decreased in a dose-dependent manner, and no tumor is detected in some mice treated with 5 mg/kg IMD-0560. The inhibitory effect of each treatment on zygoma destruction is similar, although the tumor size in the 5 mg/kg IMD-0560-treated group is smaller than that of the 3 mg/kg IMD-0560-treated group.
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• In Vitro:
  IMD-0560 inhibits TNFα-caused transcriptional activity. Pretreatment with IMD-0560 suppresses both IκBα degradation and p65 phosphorylation induced by TNFα and also strongly inhibits TNFα-induced cell invasion. Pretreatment with IMD-0560 suppresses MMP-9 activity by inhibiting MMP-9 expression.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

I kappa B kinase, Inhibitor, IkB, IkB/IKK, IKKβ, IKK, IMD 0560, IMD0560, IMD-0560, IκB, IκB kinase, inhibit

Compound Identifiers

PubChem CID

11464503