IMD-0560

SKU: orb1218028

Description

IMD-0560 is a novel inhibitor of IκB kinase β.

Key Properties

• CAS Number: 439144-66-8
• MW: 428.12
• Purity: >98% (HPLC)
• Formula: C₁₅H₈BrF₆NO₂
• SMILES: O=C(NC1=CC(C(F)(F)F)=CC=C1C(F)(F)F)C2=CC(Br)=CC=C2O
• Target: IKKβ
• Solubility: Ethanol:50 mg/mL (116.79 mM; Need ultrasonic)

Bioactivity

• In Vivo:
  The tumor size is reduced in the IMD-0560-treated groups in a dose-dependent manner, and no tumor is detected in some mice treated with 5 mg/kg IMD-0560.Zygoma destruction is significantly suppressed in the IMD-0560-treated groups compared with the control groups. Although the tumor size in the 5 mg/kg IMD-0560-treated group is smaller than that of the 3 mg/kg IMD-0560-treated group, the inhibitory effect of each treatment on zygoma destruction is similar.
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• In Vitro:
  Pretreatment with IMD-0560 inhibits both IκBα degradation and p65 phosphorylation induced by TNFα. IMD-0560 also suppresses TNFα-induced transcriptional activity. Pretreatment with IMD-0560 strongly inhibits TNFα-induced cell invasion. Pretreatment with IMD-0560 suppresses MMP-9 activity by inhibiting MMP-9 expression.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

IKKβ