IM-12

SKU: orb1226948

Description

IM-12 is a novel potent GSK-3β inhibitor with IC50 of 53 nM, significantly increases the β-catenin level and activates canonical Wnt signalling; attenuates cell proliferation of ReNcell VM cells, induces nuclear accumulation of beta-catenin.

Key Properties

• CAS Number: 1129669-05-1
• MW: 377.4115
• Purity: >98% (HPLC)
• Formula: C₂₂H₂₀FN₃O₂
• SMILES: FC(C=C1)=CC=C1CCNC(C2=O)=C(C(N2C)=O)C(C3=C(C=CC=C3)N4)=C4C
• Target: GSK-3
• Solubility: DMSO: ≥ 54.9 mg/mL

Bioactivity

• In Vitro:
  IM-12 inhibits GSK-3β in ReNcell VM cells, with I50 of 3.8 μM. IM-12 (3 μM) enhances the β-catenin amount, with no further effect at lower or higher concentration. IM-12 (3 μM) also attenuates the proliferation of ReNCell VM cells. IM-12 increases TCF-activity of ReNcell VM.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

IM 12 | IM12

Quick Database Links

Gene Symbol

GSK-3