IKKA (C) Antibody, Rabbit Polyclonal

SKU: orb67269

Description

Rabbit polyclonal to IKKA.Inhibitor of nuclear factor kappa-B kinase subunit alpha (IKKA) belongs to the protein kinasesuperfamily. IKKA is a serine kinase that plays an essential role in the NF-kappa-B signaling pathway,which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNAdamages or other cellular stresses. IKKA acts as part of the canonical IKK complex in theconventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B onserine residues. These modifications allow polyubiquitination of the inhibitors and subsequentdegradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus andactivates the transcription of hundreds of genes involved in immune response, growth control, orprotection against apoptosis. In addition, IKKA plays a key role in the negative feedback of NF-kappa-B canonical signaling to limit inflammatory gene activation.

Research Area

Epigenetics, NF-kB, Neuroscience, Signaling Pathways

Images & Validation

• Tested Applications: WB
• Dilution Range: WB:1:500-1:2000
• Reactivity: Human, Mouse

Key Properties

• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: C-terminal region of human IKKA
• Molecular Weight: 85
• Purity: Affinity purification
• Conjugation: Unconjugated

Storage & Handling

• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Buffer/Preservatives: 0.01% NaN3
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

anti-IKKA antibody,anti-Inhibitor of nuclear factor kappaB kinase subunit alpha antibody,anti-IkappaB kinase alpha antibody,anti-IKKA antibody,anti-IKKalpha antibody,anti- IkBKA antibody,anti-IkappaB kinase antibody,anti-Conserved helixloophelix ubiquitous kinase antibody,anti-IkappaB kinase 1 antibody,anti-IKK1 antibody,anti- Nuclear factor NFkappaB inhibitor kinase alpha antibody,anti-NFKBIKA antibody,anti-Transcription factor 16 antibody,anti-TCF16 antibody,anti-TCF16 antibody

Western blot analysis of total cell extracts from human Hela(Lane1),human Jurkat(Lane2) and mouse thymus(Lane2) using IKKA antibody

Quick Database Links

UniProt

O15111