IDX184

SKU: orb1741522

Description

IDX184 is a liver-targeted nucleotide prodrug and potent, orally active inhibitor of the HCV NS5B polymerase (IC50=0.31 µM). It has demonstrated anti-HCV activity in research, showing utility in both in vitro enzymatic assays and in vivo models for studying hepatitis C virus replication and combination therapies.

Research Area

Infectious Disease & Virology, Protein Biochemistry

Key Properties

• CAS Number: 1036915-08-8
• MW: 626.62
• Purity: 99.29% (May vary between batches)
• Formula: C₂₅H₃₅N₆O₉PS
• SMILES: C[C@]1(O)[C@H](N2C3=C(N=C2)C(=O)N=C(N)N3)O[C@H](COP(NCC4=CC=CC=C4)(OCCSC(C(CO)(C)C)=O)=O)[C@H]1O
• Target: HCV Protease
• Solubility: DMSO:50 mg/mL (79.79 mM)

Bioactivity

• Target IC50:
  HCV polymerase:0.31 μM (IC50)|HCV polymerase:52.3 nM (Ki)
• In Vitro:
  IDX184, a liver-targeted prodrug of the nucleotide 2′-MeG-MP, serves as a hepatitis C virus polymerase inhibitor with liver-specific targeting. IDX184 is not toxic (CC50>100μM) in any tested cell line. IDX184 is a second-generation, orally bioavailable nucleotide prodrug designed to provide increased anti-HCV efficacy and safety versus the parent nucleoside. In HCV replicon testing, IDX184 is the most potent inhibitor (EC50=0.3-0.45 μM) compared to any of the 2’ or 4’ modified nucleosides (EC50=4-6 μM) and is also highly inhibitory in the JFH-1 infectious system (EC50=0.06-0.11 μM).
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

HCV NS5B polymerase, HCV Protease, HCVProtease, IDX 184, IDX184, IDX-184

Compound Identifiers

PubChem CID

135565589