IDF-11774

SKU: orb1301713

Description

IDF-11774 is a potent small molecule inhibitor of HIF-1, demonstrating an IC50 of 3.65 μM in reducing HIF-1α HRE-driven luciferase activity. This compound is a valuable research tool for studying hypoxia signaling pathways in cancer and other diseases, with applications in both cellular and animal models.

Research Area

Cardiovascular Research, Epigenetics & Chromatin, Metabolism Research

Key Properties

• CAS Number: 1429054-28-3
• MW: 368.51
• Purity: 98.05% (May vary between batches)
• Formula: C₂₃H₃₂N₂O₂
• SMILES: CN1CCN(CC1)C(=O)COc1ccc(cc1)C12CC3CC(CC(C3)C1)C2
• Target: HIF/HIF Prolyl-Hydroxylase,HIF
• Solubility: DMSO:60 mg/mL (162.82 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.71 mM)

Bioactivity

• Target IC50:
  HIF1α:3.65 μM
• In Vivo:
  Luciferase activity and HIF-1α accumulation are significantly suppressed in the tumors of mice treated with oral administration of IDF-11774, compared to the control.
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• In Vitro:
  IDF-11774 treatment suppressed angiogenesis of cancer cells by reducing the expression of HIF-1 target genes, reduced glucose uptake, thereby sensitizing cells to growth under low glucose conditions, and decreased the extracellular acidification rate (ECAR) and oxygen consumption rate of cancer cells.
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• Animal Research:
  When IDF-11774 is orally administered daily for two weeks, significant dose-dependent tumor regression is observed in the mouse model.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Hypoxia-inducible factors, IDF 11774, IDF11774, IDF-11774, Inhibitor, HIFs, HIFProlylHydroxylase, HIF-PH, HIF-1α, HIF, HIF Prolyl-Hydroxylase, HIF ProlylHydroxylase, HIF/HIFProlylHydroxylase, HIF/HIF ProlylHydroxylase, HIF/HIF Prolyl-Hydroxylase

Compound Identifiers

PubChem CID

71542096