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IDF-11774

SKU: orb1226303

Description

IDF-11774 (IDF 11774, IDF11774) is a potent, orally bioavailable HIF-1 inhibitor that reduces the HRE-luciferase activity of HIF-1α (IC50=3.65 uM) and blocks HIF-1α accumulation under hypoxia in HCT116 human colon cancer cells; suppresses the mRNA expression of HIF-1 target genes VEGF and EPO but not HIF-1α; inhibits the accumulation of HIF-1α in vitro and in vivo in colorectal carcinoma HCT116 cells; exhibits substantial anticancer efficacy in mouse models containing KRAS, PTEN, or VHL mutations.

Images & Validation

Key Properties

CAS Number1429054-28-3
MW368.521
Purity>98% (HPLC)
FormulaC23H32N2O2
SMILESO=C(N1CCN(C)CC1)COC2=CC=C(C34C[C@H]5C[C@@](C4)([H])C[C@H](C5)C3)C=C2
TargetHIF/HIF Prolyl-hydroxylase
SolubilityDMSO : 60 mg/mL 162.82 mM

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

IDF 11774 | IDF11774

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Protocol Information

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200 mg
500 mg
5 mg
$ 190.00
10 mg
$ 320.00
25 mg
$ 520.00
50 mg
$ 770.00
100 mg
$ 1,110.00