Idasanutlin

SKU: orb1226727

Description

Idasanutlin (RG-7388) is a potent and selective p53-MDM2 inhibitor with IC50 of 6 nM.(In Vitro):Idasanutlin (RG7388) inhibits cell proliferation with IC50 of 30 nM, and induces dose-dependent p53 stabilization, cell cycle arrest, as well as cell apoptosis in cancer cells expressing wild-type p53. Idasanutlin (RG7388) (300 nM or 1.8 μM) induces apoptosis in SJSA osteosarcoma cells.(In Vivo):Idasanutlin (RG7388, 25 mg/kg p.o.) results in tumor growth inhibition and regression, in the mouse SJSA human osteosarcoma xenograft model. Idasanutlin (RG7388) induces induction of apoptosis and antiproliferation, in the SJSA xenograft model.

Key Properties

• CAS Number: 1229705-06-9
• MW: 616.48
• Purity: >98% (HPLC)
• Formula: C₃₁H₂₉Cl₂F₂N₃O₄
• SMILES: O=C(O)C1=CC=C(NC([C@@H]2N[C@@H](CC(C)(C)C)[C@](C#N)(C3=CC=C(Cl)C=C3F)[C@H]2C4=CC=CC(Cl)=C4F)=O)C(OC)=C1
• Target: MDM2-p53
• Solubility: DMSO:100 mg/mL (162.21 mM); Ethanol:8 mg/mL warmed (12.97 mM); Water：<1 mg/mL (<1 mM)

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

RG-7388

Quick Database Links

Gene Symbol

MDM2-p53