PROTAC HDAC8 Degrader-4

SKU: orb3177203

Description

PROTACHDAC8 Degrader-3 (Compound BP6) is an efficient and selective HDAC8PROTAC degrader with low cytotoxicity, exhibiting a DC50 of 80 nM. It demonstrates IC50 values of 0.26 μM for HDAC8 and 30 μM for CRBN. PROTACHDAC8 Degrader-3 enhances Ac-SMC3 levels, stabilizes p53, and sensitizes cells to targeted agents such as Idasanutlin, indicating significant potential for combination therapy.

Images & Validation

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Key Properties

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Target	PROTACs,HDAC

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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Gene Symbol

PROTACs,HDAC

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