ID-8

SKU: orb1222679

Description

ID-8 is a DYRK inhibitor. ID-8 could support Wnt-induced human embryonic stem cell proliferation and survival without differentiation. Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) is the target of the small molecule ID-8. Its role in human pluripotent cell renewal was confirmed by DYRK knockdown in human embryonic stem cells.

Key Properties

• CAS Number: 147591-46-6
• MW: 298.29
• Purity: >98% (HPLC)
• Formula: C₁₆H₁₄N₂O₄
• SMILES: COc1ccc(cc1)n1c(C)c(c2c1cc(O)cc2)[N+](=O)[O-]
• Target: DYRK
• Solubility: DMSO : ≥ 47 mg/mL; 157.56 mM

Bioactivity

• In Vitro:
  ID-8 (0.1-10 μM) increases human embryonic stem cell (hESC) survival. ID-8 (10 μM) stimulates ESCs proliferation in serum-free media for more than 1 month.
  Read more...

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ID-8 | ID 8 | ID8

Quick Database Links

Gene Symbol

DYRK