Icotrokinra

SKU: orb2664463

Description

Icotrokinra is a potent, orally active, and selective IL-23 receptor antagonist that blocks IL-23 signaling, evidenced by inhibiting STAT3 phosphorylation (IC50 = 5.6 pM) in PBMCs and reducing IFN-γ production in NK cells. Its anti-inflammatory efficacy, demonstrated in a rat TNBS-colitis model, supports research into psoriasis, psoriatic arthritis, and inflammatory bowel disease.

Research Area

Immunology & Inflammation

Key Properties

• Target: IL Receptor
• CAS Number: 2763602-16-8
• MW: 1898.17
• Purity: 98.93% (May vary between batches)
• Formula: C₉₀H₁₂₀N₂₀O₂₂S₂
• SMILES: N(C([C@H](CC1=CC2=C(C=C1)C=CC=C2)NC([C@H](CC3=CC=C(OCCN)C=C3)NC(=O)[C@H]4NC(=O)[C@H](CCCCNC(C)=O)NC(=O)[C@H](CC=5C=6C(NC5)=C(C)C=CC6)NC(=O)[C@]([C@@H](C)O)(NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(C)=O)C(C)(C)SSC4(C)C)[H])=O)=O)C7(C(N[C@H](C(N[C@H](C(N[C@@H](CC=8C=CC=NC8)C(N(CC(N)=O)C)=O)=O)CC(N)=O)=O)CCC(O)=O)=O)CCOCC7

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

JNJ2113, JNJ-2113, JNJ77242113, JNJ-77242113, PN235, PN-235

Compound Identifiers

PubChem CID

162462321