Icotrokinra

• Catalog Number: orb2664463
• Category: Small Molecules
• Description: Icotrokinra (JNJ-77242113) is an orally effective selective antagonist of the IL-23 receptor (IL-23 receptor), demonstrating high affinity with a dissociation constant (Kd) of 7.1 pM for the human IL-23 receptor (hIL-23R). It inhibits IL-23-induced STAT3 phosphorylation in PBMC with an IC50 of 5.6 pM and suppresses the production of IFNγ and IL-17A at the epidermal level induced by IL-23. Additionally, Icotrokinra exhibits anti-inflammatory activity in a rat model of TNBS-induced colitis.
• CAS Number: 2763602-16-8
• Purity: 98.00%
• MW: 1898.17
• SMILES: N(C([C@H](CC1=CC2=C(C=C1)C=CC=C2)NC([C@H](CC3=CC=C(OCCN)C=C3)NC(=O)[C@H]4NC(=O)[C@H](CCCCNC(C)=O)NC(=O)[C@H](CC=5C=6C(NC5)=C(C)C=CC6)NC(=O)[C@]([C@@H](C)O)(NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(C)=O)C(C)(C)SSC4(C)C)[H])=O)=O)C7(C(N[C@H](C(N[C@H](C(N[C@@H](CC=8C=CC=NC8)C(N(CC(N)=O)C)=O)=O)CC(N)=O)=O)CCC(O)=O)=O)CCOCC7
• Formula: C₉₀H₁₂₀N₂₀O₂₂S₂
• Storage: -20°C
• Note: For research use only
• Expiration Date: 12 months from date of receipt.