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Icotrokinra acetate

SKU: orb3180542

Description

Icotrokinra (JNJ-77242113) acetate is a potent oral selective antagonist of the IL-23 receptor. It inhibits IL-23-induced STAT3 phosphorylation in peripheral blood mononuclear cells (PBMC) with an IC50 of 5.6 pM and reduces IFN-γ production in natural killer (NK) cells induced by IL-23, with an IC50 of 18.4 pM. Icotrokinra acetate demonstrates anti-inflammatory properties in a TNBS-induced rat colitis model and is applicable to research on psoriasis, psoriatic arthritis, and inflammatory bowel diseases.

Research Area

Immunology & Inflammation, Signal Transduction, Stem Cell & Developmental Biology

Images & Validation

Key Properties

TargetInterleukin,IFNAR,STAT

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information

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