ICA-069673

SKU: orb1303514

Description

ICA-069673 is a small molecule activator of the KCNQ2/Q3 potassium channel with an IC50 of 0.69 µM. It is a valuable research tool for studying channel function in vitro and has been used in vivo to investigate its potential in models of neuronal excitability and epilepsy.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 582323-16-8
• MW: 269.63
• Purity: 99.66%
• Formula: C₁₁H₆ClF₂N₃O
• SMILES: Fc1ccc(cc1F)C(=O)Nc1cnc(Cl)nc1
• Target: Potassium Channel
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (7.42 mM);DMSO:50 mg/mL (185.44 mM)

Bioactivity

• Target IC50:
  KCNQ2/Q3:0.69 μM
• In Vitro:
  ICA-069673 is 20-fold selective for KCNQ2/Q3 over KCNQ3/Q5. It has no inhibitory against a panel of cardiac ion channels (IC50> 30 μM for hERG, Nav1.5, L type channels, and KCNQ1). ICA-069673 (10 μM) has no activity on GABA(A) gated channels. ICA-069673 exhibits much stronger effects on KCNQ2 channels, including a large hyperpolarizing shift of the voltage-dependence of activation, a 2-fold enhancement of peak current and pronounced subtype specificity for KCNQ2 over KCNQ3.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Potassium Channel, PotassiumChannel, inhibit, KcsA, KCNQ2/Q3 potassium channel, Inhibitor, ICA 069673, ICA069673, ICA-069673

Compound Identifiers

PubChem CID

10149311