IACS-13909

SKU: orb1218441

Description

IACS-13909, a specific and potent allosteric inhibitor of SHP2, that suppresses signaling through the MAPK pathway.

Key Properties

• CAS Number: 2160546-07-4
• MW: 377.27
• Purity: >98% (HPLC)
• Formula: C₁₇H₁₈Cl₂N₆
• SMILES: NC1(C)CCN(C2=CN=C3C(NN=C3C4=CC=CC(Cl)=C4Cl)=N2)CC1
• Target: Phospholipase
• Solubility: DMSO:9 mg/mL (23.86 mM; Need ultrasonic)

Bioactivity

• In Vivo:
  Animal model: NSG mice (20-28 g) injected with KYSE-520 cells. Dosage: 70 mg/kg. Administration: Oral administration; daily; for 21 days. Result: Potently suppressed tumor growth in mice.
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• In Vitro:
  Cell Proliferation Assay Cell line: Wild-type SHP2 and KYSE-520 cells. Concentration: 10 nM, 100 nM, 1 μM, 10 μM. Incubation time: 14 days. Result: Potently suppressed the cell proliferation. Western blot analysis. Cell line: Wild-type SHP2 and KYSE-520 cells. Concentration: 1 μM, 5 μM. Incubation time: 2 hours. Result: Potently suppressed pERK and pMEK levels.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BBP-398 | IACS 13909

Quick Database Links

Gene Symbol

Phospholipase