IACS-13909

SKU: orb1298292

Description

IACS-13909

Research Area

Metabolism Research

Key Properties

• CAS Number: 2160546-07-4
• MW: 377.27
• Purity: 98.83% (May vary between batches)
• Formula: C₁₇H₁₈Cl₂N₆
• SMILES: CC1(N)CCN(CC1)c1cnc2c(n[nH]c2n1)-c1cccc(Cl)c1Cl
• Target: Phosphatase
• Solubility: DMSO:9 mg/mL (23.86 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.65 mM)

Bioactivity

• Target IC50:
  SHP2:15.7 nM
• In Vivo:
  In EGFR-mutant osimertinib-resistant NSCLC models with EGFR-dependent and EGFR-independent resistance mechanisms, IACS-13909, administered as a single agent or in combination with osimertinib, potently suppressed tumor cell proliferation in vitro and caused tumor regression in vivo.
  Read more...
• In Vitro:
  IACS-13909 potently impeded proliferation of tumors harboring a broad spectrum of activated RTKs as the oncogenic driver.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

RTK, pERK, SHP-2, SHP2, Phosphatase, BBP 398, BBP398, BBP-398, BBP-398, antiproliferative, anticancer, IACS13909, IACS-13909, IACS 13909, MAPK, Inhibitor, inhibit, pMEK

Compound Identifiers

PubChem CID

132166923