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I-CBP112

SKU: orb1226008

Description

A specific and potent inhibitor of CBP/p300 bromodomain with Kd of 150-170 nM; displaces H3K56ac from the CBP binding site with an IC50 of 170 nM; demonstrates 37-fold and 132-fold selectivity over BRD4 BD1 and BRD4 BD2, respectively; increases the cytotoxic activity of JQ1 in leukemic cells; impaires the disease-initiating self-renewal leukemic cells in vitro and in vivo without causing significant cytotoxicity.

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Key Properties

CAS Number1640282-31-0
MW468.5851
Purity>98% (HPLC)
FormulaC27H36N2O5
SMILESCCC(N1CCOC2=C(OC[C@@H]3CN(C)CCC3)C=C(C4=CC=C(OC)C(OC)=C4)C=C2C1)=O
TargetHAT
SolubilityDMSO: ≥ 32 mg/mL

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

I-CBP112 | I-CBP-112 | I-CBP 112

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Protocol Information

I-CBP112 (orb1226008)

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Available Sizes

Select a size below

200 mg
500 mg
2 mg
$ 140.00
5 mg
$ 240.00
10 mg
$ 400.00
25 mg
$ 730.00
50 mg
$ 1,040.00
100 mg
$ 1,410.00