I-CBP112 hydrochloride

• Catalog Number: orb1303026
• Category: Small Molecules
• Description: I-CBP112 hydrochloride
• CAS Number: 2147701-33-3
• Purity: 97.98%
• MW: 505.05
• SMILES: O(C[C@@H]1CN(C)CCC1)C2=C3C(=CC(=C2)C4=CC(OC)=C(OC)C=C4)CN(C(CC)=O)CCO3.Cl
• Formula: C₂₇H₃₇ClN₂O₅
• Biological Activity: I-CBP112 is a selective inhibitor of the bromodomain-containing transcription factors. I-CBP112 (1 mM) has little activity against other bromodomains. I-CBP112 targets the CBP/p300 bromodomains. I-CBP112 significantly reduced the leukemia-initiating potential of MLL-AF9(+) acute myeloid leukemia cells in a dose-dependent manner in vitro and in vivo. Interestingly, I-CBP112 increased the cytotoxic activity of BET bromodomain inhibitor JQ1 as well as doxorubicin.
• Note: For research use only
• Expiration Date: 12 months from date of receipt.