Hypericin

SKU: orb1300234

Description

Hypericin

Research Area

Cell Biology, Neuroscience

Key Properties

• CAS Number: 548-04-9
• MW: 504.45
• Purity: >98%
• Formula: C₃₀H₁₆O₈
• SMILES: Cc1cc(O)c2c3c1c1c(C)cc(O)c4c1c1c3c3c(c(O)cc(O)c3c2=O)c2c(O)cc(O)c(c12)c4=O
• Target: Monoamine oxidase
• Solubility: Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 5 mg/ml).

Bioactivity

• Target IC50:
  Fibroblasts:1.75 μM (LD50)|keratinocytes:4 μM (LD50)|Hvr100-6:22.9 ± 1.4 mM|NPYY1 receptor:3-4 μM|Y2 receptor:3-4 μM|Tyrosine kinase:7.5 μM|HeLa cells:17.2 ± 3.3 mM|melanocytes:3.5 μM (LD50)|MCF-7 cells:5 µg/mL (LD50)
  Read more...
• In Vivo:
  METHODS: To investigate the role of DR5 activation in the heart, Bioymifi (5 mg/kg/d) micro-osmotic pump was administered to C57BL/6 mice once daily for two weeks. RESULTS: Bioymifi administration resulted in hypertrophy at the level of cardiac organs and cardiomyocytes, but did not affect cardiomyocyte death or cardiac fibrosis.
  Read more...
• In Vitro:
  METHODS: Erythrocytes were treated with Bioymifi (10-100 µM) for 24 h. Flow cytometry was used to characterize the hemolytic and bactericidal properties of Bioymifi and the potential molecular mechanisms. RESULTS: Bioymifi exerted a dose-responsive, calcium-independent hemolytic effect, reduced erythrocyte hemoglobin, and significantly increased membrane-bound protein V, Fluo4, and DCF-positive cells, as well as a dual effect on forward and lateral light scattering. METHODS: Neonatal rat ventricular myocytes (nrvm) were treated with Bioymifi (10 µM) for 24 h, and the expression levels of target proteins were detected by Western Blot. RESULTS: The expression of DR5 was higher than that of NRVF in Bioymifi-treated nrvm.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

keratinocytes, inhibit, Influenza Virus, InfluenzaVirus, Inhibitor, MAO, Monoamine Oxidase, monoaminoxidase, melanocytes, Hypericin, Hypericine, Hypericum, fibroblasts, Cytochrome P450, Cyclosan, CYPs, Dopamine beta-hydroxylase, Dopamine beta-monooxygenase, Dopamine β-hydroxylase, Dopamine β-monooxygenase, antidepressive activity, antibacterial, Antibiotic, antiviral activity, antiviral, antitumor activity, Apoptosis, Telomerase, telomerase and CYP, Reverse Transcriptase, PKC, Protein kinase C, TyrosineKinases, Tyrosine Kinases, tyrosine kinases

Compound Identifiers

PubChem CID

137629134