Hydralazine hydrochloride

SKU: orb1308014

Description

Hydralazine hydrochloride

Research Area

Cell Biology, Epigenetics & Chromatin, Metabolism Research, Neuroscience, Protein Biochemistry

Key Properties

• CAS Number: 304-20-1
• MW: 196.64
• Purity: 99.86%
• Formula: C₈H₉ClN₄
• SMILES: NNC1=NN=CC2=CC=CC=C12
• Target: Caspase,MAO,HIF/HIF Prolyl-Hydroxylase,Bcl-2 Family,Apoptosis
• Solubility: H2O:10 mM;DMSO:Insoluble

Bioactivity

• In Vivo:
  Hydralazine affords strong, dose-dependent protection agains the increases in plasma marker enzymes but no the hepatic glutathione depletion produced by allyl alcohol in mice.
• In Vitro:
  Hydralazine impairs up-regulation of RAG-2 gene expression and reduces secondary Ig gene rearrangements. Hydralazine subverts B lymphocyte tolerance to self and contributes to generation of pathogenic autoreactivity by disrupting receptor editing. Hydralazine directly scavenges free acrolein, decreasing intracellular acrolein availability and thereby suppressing macromolecular adduction. Hydralazine inhibits cross-linking if adding 30 min after commencing acrolein exposure but is i effective if added after a 90 min delay. Hydralazine (0.1-10 mM) inhibits both extracellular and intracellular ROS production by inflammatory macrophages, by a ROS-scavenging mechanism probably affecting superoxide radical (O(2)(*-))-generation by xanthine oxidase (XO) and nicotinamide adenine dinucleotide/nicotinamide adenine dinucleotide phosphate (NADH/NADPH) oxidase. Hydralazine (0.1-10 mM) significantly reduces NO(*) generation, and this effect is attributable to an Inhibition of NOS-2 gene expression and protein synthesis. Hydralazine also effectively blocks COX-2 gene expression which perfectly correlated with a reduction of protein levels and PGE(2) synthesis. Hydralazine protects against not only acrolein-mediated injury, but also compression in guinea pig spinal cord ex vivo. Hydralazine can significantly alleviate acrolein-induced superoxide production, glutathione depletion, mitochondrial dysfunction, loss of membrane integrity, and reduces compound action potential conduction.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

antihypertensive, Apresoline, arterial vessel, Inhibitor, HIF, HIF/HIFProlylHydroxylase, HIF/HIF Prolyl-Hydroxylase, HIF ProlylHydroxylase, HIF/HIF ProlylHydroxylase, HIF Prolyl-Hydroxylase, HIF-PH, HIFProlylHydroxylase, HIFs, MAO, Hypoxia-inducible factors, Hydralazine, Hydralazine HCl, Hydralazine Hydrochloride, Hydralazine hydrochloride, inhibit, orally active

Compound Identifiers

PubChem CID

3637