Human IL-22 R alpha 1 Protein

• Catalog Number: orb1289953
• Category: Proteins
• Description: Interleukin-22 receptor subunit alpha-1(IL22RA1) is a component of the receptor for IL20, IL22 and IL24.Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation.
• Reactivity: Human
• Tag: C-Fc
• Form/Appearance: Powder
• Purity: 95%
• Conjugation: Unconjugated
• MW: 50.9 kDa
• Target: IL-22 R alpha 1
• Source: Human IL-22 R alpha 1, Fc Tag (orb1289953) is expressed from human 293 cells (HEK293). It contains AA His 16 - Thr 228 (Accession # Q8N6P7-1).
• Expression System: HEK293
• Biological Activity: Loaded Human IL-22 R alpha 1 Protein, Fc Tag on Protein A Biosensor, can bind Human IL-24 Protein, His Tag with an affinity constant of 1.71 μM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).
• Expression Region: His 16 - Thr 228
• Endotoxins: 1.0 EU per μg
• NCBI: NP_067081.2
• Storage: -20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
• Buffer/Preservatives: 51 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5
• Alternative names: Interleukin-22 receptor subunit alpha-1,IL-22 rece
• Note: For research use only
• Application notes: This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 50.9 kDa. The protein migrates as 60-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
• Expiration Date: 6 months from date of receipt.

Loaded Human IL-22 R alpha 1 Protein, Fc Tag (Cat. No. orb1289953) on Protein A Biosensor, can bind Human IL-24 Protein, His Tag (Cat. No. orb1496282) with an affinity constant of 1.71 μM as determined in BLI assay (ForteBio Octet Red96e) (Routinely tested).