Human IL-22 R alpha 1 & IL-10 R beta Heterodimer Protein, Fc Tag&Fc Tag (MALS verified)

SKU: orb3032196

Description

Interleukin-22 receptor subunit alpha-1(IL22RA1) is a component of the receptor for IL20, IL22 and IL24.Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation.

Images & Validation

• Application Notes:
  Human IL-22 R alpha 1 & IL-10 R beta Heterodimer Protein, Fc Tag&Fc Tag is produced by co-expression of IL-22 R alpha 1 and IL-10 R beta, has a calculated MW of 50.6 kDa & 49.7 kDa. Subunit IL-22 R alpha 1 is fused with a human IgG1 Fc tag at the C-terminus and subunit IL-10 R beta is fused with a human IgG1 Fc tag at the C-terminus. The protein migrates as 63-93 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

Key Properties

• Expression System: HEK293
• Target: IL-22 R alpha 1 & IL-10 R beta
• Reactivity: Human
• Tag: C-Fc | C-Fc
• Molecular Weight: 50.6 kDa & 49.7 kDa
• Expression Region: Pro 18 - Thr 228 & Met 20 - Ser 220
• Purity: 95%
• Conjugation: Unconjugated

Storage & Handling

• Storage: -20°C to -70°C for 12 months in lyophilized state;. -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower
• Form/Appearance: Powder
• Buffer/Preservatives: PBS, pH 7.4
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

IL-22 R alpha 1 & IL-10 R beta