Human Full-Length Membrane Proteins   
Synthetic Nanodisc Platform

Native Conformation Functional Activity MSP-Free Mammalian Expression System

60% of Known Drug Targets Are Membrane Proteins

Aberrant membrane protein function is a central driver of numerous diseases, establishing them as "golden targets" in drug development. Currently, over 60% of drug targets are transmembrane proteins, and among antibody-based therapeutics, this figure exceeds 90%. Obtaining full-length membrane proteins with a "native conformation" and "functional activity" represents a critical bottleneck.

Leveraging its innovative Synthetic Nanodisc technology platform, Biorbyt delivers highly purified, soluble, full-length membrane proteins that retain native activity.

Synthetic Nanodisc

Synthetic Nanodiscs employ synthetic polymers to solubilize the cell membrane while utilizing native cellular phospholipids to form a nanodisc structure. The polymer integrates the membrane protein into the nanodisc, preserving its native spatial conformation and activity.

MSP-Free Scaffold Purified single-protein format.

Mammalian Expression System Ensures post-translational modifications (phosphorylation, glycosylation).

Detergent-Free Enables direct use in cell-based assays.

Advantages and Applications

Preparation Method	Advantages	Applications
Synthetic Nanodisc	• Highly purified membrane proteins • High solubility & stability • Maintains biological activity • Detergent-Free • Mammalian expression system	• ELISA & SPR affinity analysis • Phage display screening • Immunization • Cell-based assays • Structural analysis

Product Validation Data

Human CLDN6 full-length protein-synthetic nanodisc

Cat#: orb1291766 

SAS-PAGE

ELISA assay

Human CCR8 full-length protein-synthetic nanodisc

Cat#: orb1743234 

ELISA assay

WB analysis

SPR assay

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Membrane Protein Scaffold Systems

In the development of multi-spanning membrane drug targets, full-length membrane proteins with native conformation represent the optimal antigens. Achieving this goal requires the selection of an appropriate membrane protein scaffold system. Currently, nanodisc technology based on different scaffold materials is primarily classified into the following three categories:

Type	Scaffold Composition	Key Features	Typical Applications
MSP Nanodisc	Membrane scaffold protein (derived from ApoA1)	Most established; uniform size (7–17 nm); genetically engineerable	Cryo-EM, NMR structural determination
Synthetic Nanodisc	SMA / DIBMA copolymers	Directly "punched out" from cell membranes; preserves native lipids	Rapid membrane protein purification; functional studies
PeptiNanodisc	Short amphipathic peptides	No pre-mixing of lipids required; "universal" scaffold; simple operation	High-throughput screening; membrane protein purification

Explore Synthetic Nanodisc Series Explore PeptiNanodisc Series

Biorbyt offers custom services for full-length human membrane proteins as well as other recombinant proteins, ensuring a consistent and reliable supply for drug development projects.

Inquire about Custom Services