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HPK1-IN-7

SKU: orb1940192

Description

HPK1-IN-7 is an orally active HPK1 inhibitor. It shows selectivity against IRAK4 (59 nM) and GLK (140 nM).

Research Area

Signal Transduction

Images & Validation

Key Properties

CAS Number2320462-65-3
MW458.478
Purity>98% (HPLC)
FormulaC24H22N6O4
SMILESCC1(C)OC(=O)c2ccc(Nc3ncc(-c4nnco4)c(N[C@H](CO)c4ccccc4)n3)cc12
Targetp38 MAPK
SolubilityIn Vitro: DMSO : 125 mg/mL (272.65 mM)

Bioactivity

In Vivo
Animal model: Mice (MC38 syngeneic tumor model). Dosage: 100 mg/kg. Administration: Oral; twice daily for 28 days. Result: Enhanced the efficacy of anti-PD1 treatment, garnering a 100% cure rate vs a 20% cure rate with anti-PD1 alone.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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  • HPK1-IN-7 [orb1298074]

    99.79% (May vary between batches)

    2320462-65-3

    458.47

    C24H22N6O4

    50 mg, 5 mg, 10 mg, 25 mg, 100 mg, 1 mg, 1 ml x 10 mM (in DMSO), 200 mg
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Protocol Information

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