HPK1-IN-7

SKU: orb1298074

Description

HPK1-IN-7 is an orally bioavailable, small molecule inhibitor of Hematopoietic Progenitor Kinase 1. It demonstrates selectivity over related kinases IRAK4 (IC50 = 59 nM) and GLK (IC50 = 140 nM). This compound is a valuable research tool for investigating HPK1 function in immune cell signaling and for preclinical studies in immuno-oncology.

Research Area

Signal Transduction

Key Properties

• CAS Number: 2320462-65-3
• MW: 458.47
• Purity: 99.79% (May vary between batches)
• Formula: C₂₄H₂₂N₆O₄
• SMILES: CC1(C)OC(=O)c2ccc(Nc3ncc(-c4nnco4)c(N[C@H](CO)c4ccccc4)n3)cc12
• Target: MAPK
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (8.72 mM);DMSO:125 mg/mL (272.65 mM)

Bioactivity

• Target IC50:
  MST1:55.1 nM (IC50)|GLK/MAP4K3:140 nM (IC50)|FLT3:25.4 nM (IC50)|AMPK α1:44.3 nM (IC50)|MST2:78.5 nM (IC50)|FMS:3.2 nM (IC50)|c-Kit:45.7 nM (IC50)|IRAK4:59 nM (IC50)|HPK1:2.6 nM (IC50)|ICK:65.1 nM (IC50)
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

MAP4K, MAPK Kinase Kinase Kinase, MC38, HPK1 IN 7, HPK1IN7, HPK-1-IN-7, HPK1-IN-7, inhibit, Inhibitor, oral, model, PD1, selectivity, tumor

Compound Identifiers

PubChem CID

142587219