HNMPA

SKU: orb1306211

Description

HNMPA is a cell-impermeant inhibitor that selectively blocks the tyrosine kinase activity of the insulin receptor, inhibiting its autophosphorylation on tyrosine and serine residues without affecting cAMP-dependent protein kinase or PKC. This tool compound is used in vitro to study insulin signaling mechanisms, receptor tyrosine kinase function, and metabolic research.

Research Area

Signal Transduction

Key Properties

• CAS Number: 132541-52-7
• MW: 238.18
• Purity: 99.18% (May vary between batches)
• Formula: C₁₁H₁₁O₄P
• SMILES: C(P(=O)(O)O)(O)C1=CC2=C(C=C1)C=CC=C2
• Target: IGF-1R
• Solubility: DMSO:55 mg/mL (230.92 mM)

Bioactivity

• In Vitro:
  HNMPA reduces neuronal firing after GABA application and blocks GABA-dependent insulin inhibition. HNMPA has no effect on cyclic AMP-dependent protein kinase or protein kinase C activities.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, HNMPA, IGF1R, Insulin Receptor, serine autophosphorylation, tyrosine kinase, tyrosine autophosphorylation

Compound Identifiers

PubChem CID

129317