HNMPA-(AM)3

SKU: orb1693606

Description

HNMPA-(AM)3 is a cell-permeable inhibitor of insulin receptor tyrosine kinase activity, blocking PTTH-stimulated ERK phosphorylation and ecdysteroidogenesis. It is utilized in insect endocrinology and comparative signaling research, with applications in both in vitro and in vivo studies to investigate insulin-related pathways in development and metabolism.

Research Area

Signal Transduction

Key Properties

• CAS Number: 120944-03-8
• MW: 454.36
• Purity: 97.22% (May vary between batches)
• Formula: C₂₀H₂₃O₁₀P
• SMILES: O=C(OCOC(C=1C=CC=2C=CC=CC2C1)P(=O)(OCOC(=O)C)OCOC(=O)C)C
• Target: Tyrosine Kinases,IGF-1R
• Solubility: Ethanol:25 mg/mL (55.02 mM);DMF:5 mg/mL (11 mM);PBS (pH 7.2):1 mg/mL (2.2 mM);DMSO:80 mg/mL (176.07 mM)

Bioactivity

• Target IC50:
  insulin receptor (mammalian):14.2 μM|insulin receptor (mosquito):200 μM|ecdysteroid production:14.2 μM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

HNMPA (AM)3, HNMPA(AM)3, HNMPA-(AM)3, Tyrosine Kinases, TyrosineKinases

Compound Identifiers

PubChem CID

3619