HMN-154

SKU: orb1303286

Description

HMN-154 is a novel benzenesulfonamide compound that acts as a transcriptional inhibitor by targeting the NF-YB subunit, thereby disrupting NF-Y heterotrimer binding to DNA. This mechanism supports its investigation in cancer research, with studies exploring its effects on tumor cell proliferation in both in vitro and in vivo models.

Key Properties

• CAS Number: 173528-92-2
• MW: 366.43
• Purity: 97.71%
• Formula: C₂₀H₁₈N₂O₃S
• SMILES: COc1ccc(cc1)S(=O)(=O)Nc1ccccc1\C=C\c1ccncc1
• Target: Others
• Solubility: DMSO:15 mg/mL (40.94 mM)

Bioactivity

• Target IC50:
  Colon38 cells:0.003 μg/mL|KB:0.0026 μg/mL

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

HMN154, HMN-154, HMN 154, Inhibitor, inhibit

Compound Identifiers

PubChem CID

6366736